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First, it is an endogenous molecule: it circulates in human plasma at a concentration of roughly 200 ng/mL around age 20, declining to about 80 ng/mL by age 60, a fall that has been linked, at least associatively, to the general decline in tissue regenerative capacity with age

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M1-like macrophages, also known as conventionally activated macrophages, are key players in pro-inflammatory responses

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A particular advantage for revealing this concept (i.e., BPC 157 therapy, a native cytoprotective gastric pentadecapeptide, not degraded in human gastric juice, safe (lethal dose (LD1) not achieved), no adverse effect in clinical trials (i.e., ulcerative colitis) (for a review, see [6,18,19])) in practice, and in the spinal cord injury, in particular, is its very safe profile

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